先端生命科学科 細胞社会学
研究業績
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Kira A, Tatsutomi I, Saito K, Murata M, Hattori I, Kajita H, Muraki N, Oda Y, Satoh S, Tsukamoto Y, Kimura S, Onoue K, Yonemura S, Arakawa S, Kato H, Hirashima T, Kawane K: Extracellular vesicle formation via local phosphatidylserine exposure promotes efficient cell extrusion. Dev Cell. 58 : 1282-98, 2023
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Horiguchi H, Endo M, Kawane K, Kadomatsu T, Terada K, Morinaga J, Araki K, Miyata K, Oike Y: ANGPTL2 expression in the intestinal stem cell niche controls epithelial regenerationand homeostasis. EMBO J. 36: 409-424, 2017
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Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh S, Ohto U, Shimizu T, Barber GN, Miyake K: DNase II-dependent DNA digestion is required for DNA sensing by TLR9 degradation. Nat Commun. 6: 5853, 2015
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Kawane K, Nagata S : DNA degradation and its defects. Cold Spring Harb Perspect Biol, 2014
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Nagata S, Kawane K : Autoinflammation by endogenous DNA. Adv Immunol. 110: 139-61, 2011
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Kawane K, Tanaka H, Kitahara Y, Shimaoka S, Nagata S : Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proc Natl Acad Sci U S A. 107: 19432-7, 2010
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Kitahara Y, Kawane K, Nagata S : Interferon-induced TRAIL-independent cell death in DNase II-/- embryos. Eur J Immunol. 40: 2590-8, 2010
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Ostberg T, Kawane K, Nagata S, Yang H, Chavan S, Klevenvall L, Bianchi ME, Harris HE, Andersson U, Palmblad K : Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model. Arthritis Rheum. 62: 2963-72, 2010
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Nagata S, Hanayama R, Kawane K : Autoimmunity and the clearance of dead cells. Cell. 140: 619-30, 2010
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Nagasaka A, Kawane K, Yoshida H, Nagata S : Apaf-1-independent programmed cell death in mouse development. Cell Death Differ. 17: 931-41, 2010
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Kawane K : Molecular mechanisms and physiological roles of DNA degradation. Seikagaku. 81: 765-79, 2009
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Okabe Y, Kawane K, Nagata S : IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation. Eur J Immunol. 38: 3150-8, 2008
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Kawane K, and Nagata S : Nucleases in Programmed Cell Death. Methods Enzymol. 442: 271-87, 2008
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Nakahara M., Nagasaka A, Koike M, Uchida K., Kawane K, Uchiyama Y, Nagata S : Degradation of nuclear DNA by DNase II-like Acid DNase in cortical fiber cells of mouse eye lens. FEBS J. 274: 3055-64, 2007
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Kawane K, Ohtani M, Miwa K, Kizawa T, Kanbara Y, Yoshioka Y, Yoshikawa H, Nagata S : Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature. 443: 998-1002, 2006
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Bergsmedh A, Ehnfors J, Kawane K. Motoyama N, Nagata S, Holmgren L : DNase II and the Chk2 DNA Damage Pathway Form a Genetic Barrier Blocking Replication of Horizontally Transferred DNA. Mol Cancer Res. 4: 187-95, 2006
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Okabe Y, Kawane K, Akira S, Taniguchi T, Nagata S : Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp Med. 202: 1333-9, 2005
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Yoshida H, Kawane K, Koike M, Mori Y, Uchiyama Y, Nagata S : Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells. Nature. 437: 754-8, 2005
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Yoshida H, Okabe Y, Kawane K, Fukuyama H, Nagata S : Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol. 6: 49-56, 2005
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Nishimoto S, Kawane K, Watanabe-Fukunaga R, Fukuyama H, Ohsawa Y, Uchiyama, Y, Hashida N, Ohguro N, Tano Y, Morimoto T, Fukuda Y, Nagata S : Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens. Nature. 424: 1071-4, 2003
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Kawane K, Fukuyama H, Yoshida H, Nagase H, Ohsawa Y. Uchiyama Y, Okada K, Iida T, Nagata S : Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat. Immunol. 4: 138-144, 2003
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Nagata S, Nagase H, Kawane K, Mukae N, Fukuyama H : Degradation of chromosomal DNA during apoptosis. Cell Death Differ. 10: 108-116, 2003
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Nagase H, Fukuyama H, Tanaka M, Kawane K Nagata S : Mutually regulated expression of caspase-activated DNase and its inhibitor for apoptotic DNA fragmentation. Cell Death Differ. 10: 142-3, 2003
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Kawane K, Fukuyama H, Kondoh G, Takeda J, Ohsawa Y, Uchiyama Y, Nagata S : Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science. 292: 1546-9, 2001
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Kawane K, Fukuyama H, Adachi M, Sakahira H, Copeland NG, Gilbert DJ, Jenkins NA, Nagata S : Structure and promoter analysis of murine CAD and ICAD genes. Cell Death Differ. 6: 745-52, 1999
和文
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川根公樹. 上皮細胞の終焉様式である細胞脱落. 臨床免疫・アレルギー科 71: 127-133, 2019.
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川根公樹. DNA分解の生理的および病理的意義. 臨床免疫・アレルギー科 63: 461-465, 2015.
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川根公樹, 長田重一. DNAの分解異常による関節炎. 炎症と免疫 Vol.19 No.2: 128-133, 2011.
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川根公樹. DNA分解の分子機構及び生理作用. 生化学 Vol.81: 765-769, 2009.
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川根公樹, 長田重一. DNAの分解異常による関節炎. Inflammation and Regeneration Vol.29: 204-208, 2009.
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川根公樹, 長田重一. DNAの分解異常による関節炎. 実験医学 Vol.25 No.4: 507-510, 2007.
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川根公樹, 福山英啓, 長田重一. 赤血球の脱核機序の新しい展開. Annual Review 血液 2003 42-49, 2003.
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川根公樹, 福山英啓, 長田重一. 赤血球造血機構におけるDNase IIの役割. 実験医学 Vol.19 No.14: 1858-1860, 2001.